At the outbreak of war, the Regiment was based in India, part of the Mhow Cavalry Brigade and were deployed to France as part of 2nd Indian Cavalry Division, landing there at the end of 1914.

In September 1915, the Brigade transferred to 1st Indian Cavalry Division, which was renamed a year later as 4th Cavalry Division.

The Division was broken up in early 1918 and the Regiment then transferred to 7th Cavalry Brigade, 3rd Cavalry Division.

The Regiment's principal Battle Honours were:

Somme '1916', '1918'.

Morval.

Cambrai, '1917', '1918'.

St Quentin.

Avre.

Amiens.

Hindenburg Line.

St Quentin Canal.

Pursuit to Mons.

France and Flanders, '1914-1918'.

192 men from the 6th Inniskilling Dragoons are listed in the CWGC database of First World War deaths:

1914 - 35.

1915 - 13.

1916 - 19.

1917 - 62.

1918, up to 11th Nov - 49.

After 11th Nov 1918 - 14.